1-甲基-1-亞硝基-3-((2S,3R,4R,5S,6R)-2,4,5-三羥基-6-(羥甲基)四氫-2H-吡喃-3-基)脲

ChemLeader 98+%

Streptozotocin (Synonyms: Streptozocin; Streptozocin; NSC-85998; U 9889; 鏈脲菌素; 鏈脲佐菌素)

產品編號：CL1016 CAS No.：18883-66-4 MDLNo：MFCD00006607 分子式：C8H15N3O7 分子量：265.22

加入收藏分享給朋友

規格	庫存	目錄價	會員專享價	數量
50 mg	In-stock	￥316.00	登錄后可見	- +
100 mg	In-stock	￥466.00	登錄后可見	- +
200 mg	In-stock	￥788.00	登錄后可見	- +

化學品安全說明書(MSDS)

下載MSDS

質檢證書(COA)

下載COA

發送詢價加入購物車

基本信息
相關文檔
產品詳情
相關文獻

基本信息

英文名稱	Streptozotocin (Synonyms: Streptozocin; Streptozocin; NSC-85998; U 9889; 鏈脲菌素; 鏈脲佐菌素)
中文名稱	1-甲基-1-亞硝基-3-((2S,3R,4R,5S,6R)-2,4,5-三羥基-6-(羥甲基)四氫-2H-吡喃-3-基)脲
CAS號	18883-66-4
分子式	C8H15N3O7
分子量	265.22
MDL	MFCD00006607
外觀	Light yellow powder
儲存條件	-20°C, sealed storage, away from moisture and light

產品詳情

Streptozotocin (STZ) is a glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals. It specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA. DNA damage induces activation of poly ADP-ribosylation, depletion of cellular NAD+ and ATP, and formation of superoxide radicals, leading to the destruction of beta cells.The effectiveness of STZ depends on the level of GLUT2 expression, which in turn may be influenced by age, sex, strain, or species.

Int J Mol Sci. 2023 Mar 8;24(6):5210.

PMID: 26331889 DOI: 10.1002/0471141755.ph0547s70

PMID: 25573197 DOI: 10.1016/j.imlet.2014.12.006

PMID: 16354401 DOI: 10.1211/jpp.57.12.0007

相關產品

抱歉，暫時沒有相關產品

瀏覽記錄

CL1016

1-甲基-1-亞硝基-3-((2S,3R,4R,5S,6R)-2,4,5-三羥基-6-(羥甲基)四氫-2H-吡喃-3-基)脲

18883-66-4 98+% In-stock

￥316.00 50 mg