首页 > 产品目录 > 信号通路 > Cell Cycle | 细胞周期 > TOPK > OTS514 hydrochloride

OTS514 hydrochloride

ChemLeader 98+%

OTS514 hydrochloride

产品编号：CL2491A CAS No.：2319647-76-0 MDLNo： 分子式：C21H21ClN2O2S 分子量：400.92

加入收藏分享给朋友

规格	库存	目录价	会员专享价	数量
1 mg	3-5days	￥500.00	登录后可见	- +
5 mg	3-5days	￥1500.00	登录后可见	- +
10 mg	3-5days	￥2600.00	登录后可见	- +

化学品安全说明书(MSDS)

下载MSDS

发送询价加入购物车

基本信息
相关文档
产品详情
相关文献

基本信息

英文名称	OTS514 hydrochloride
中文名称	OTS514 hydrochloride
CAS号	2319647-76-0
分子式	C21H21ClN2O2S
分子量	400.92
外观	Light yellow to yellow powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

OTS514 HCl (OTS 514; OTS-514), the hydrochloride salt of OTS514, is a novel and highly potent inhibitor of the TOPK (T-LAK cell-originated protein kinase) with potential antineoplastic activity. Its IC50 value of 2.6 nM indicates that it inhibits TOPK. The growth of TOPK-positive cancer cells was significantly suppressed by it. Moreover, it demonstrates a strong growth-inhibitory effect on ovarian cancer cell lines, with IC50 values ranging from 3.0 to 46 nM. OTS514 can cause apoptotic cell death in small cell lung cancer by exhibiting growth inhibitory effects, with an IC50 range of 0.4 ~ 42.6 nM. The activity of a protein involved in the stemness of CSC, forkhead box protein M1 (FOXM1), was also suppressed by OTS514. Additionally, OTS514 treatment exhibited increased cytotoxicity against lung sphere-derived CSC-like SCLC cells and decreased CD90-positive SCLC cells.