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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
1 mg	3-5days	￥850.00	登錄后可見	- +
5 mg	3-5days	￥2688.00	登錄后可見	- +

基本信息

英文名稱	Cyclosporin H
中文名稱	環(huán)孢菌素H
CAS號	83602-39-5
分子式	C62H111N11O12
分子量	1202.63
外觀	Amorphous white powder
儲存條件	Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).

安全信息

產(chǎn)品詳情

Cyclosporin H (CsH) is a potent and selective FPR antagonist. In human neutrophils, cyclosporin H inhibited FMLP-induced superoxide anion (O2-) formation. CsH inhibited the binding of FMLP (3 nM) to HL-60 membrane with IC50 and Ki values of 0.7 μM and 0.10 μM, respectively. CsH inhibited GTP hydrolysis stimulated by FMLP (100 nM) with IC50 and Ki values of 1.3 μM and 0.79 μM, respectively. CsH also inhibited the increase of [Ca2+Ii, O2- formation and β-glucuronidase release induced by FMLP with IC50 values of 0.23, 0.6 and 2.2 μM, and with Ki values of 0.08, 0.24, and 0.45 μM, respectively. In peripheral blood basophils, CsH (8-800 nM) competitively and concentration-dependently inhibited leukotriene C4 and histamine release activated by FMLP. In eosinophils isolated from bronchoalveolar lavage fluid of mice challenged with inhaled allergen, cyclosporin H increased apoptosis in the presence of 10 U/ml interleukin 5 in a concentration-dependent way. Cyclosporin H also increased apoptosis in the presence of 10 U/ml GM-CSF, but to a lesser extent .

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瀏覽記錄

CL1067

環(huán)孢菌素H

83602-39-5 90+% 3-5days

￥850.00 1 mg

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環(huán)孢菌素H

Cyclosporin H

化學品安全說明書(MSDS)

質(zhì)檢證書(COA)