GSK2606414;GSK 2606414

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GSK2606414;GSK 2606414

產品編號：CL1098 CAS No.：1337531-36-8 MDLNo： 分子式：C24H20F3N5O 分子量：451.44

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規格	庫存	目錄價	會員專享價	數量
20 mg	In-stock	￥520.00	登錄后可見	- +
50 mg	In-stock	￥850.00	登錄后可見	- +
100 mg	In-stock	￥1450.00	登錄后可見	- +

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基本信息
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基本信息

英文名稱	GSK2606414;GSK 2606414
中文名稱	GSK2606414;GSK 2606414
CAS號	1337531-36-8
分子式	C24H20F3N5O
分子量	451.44
外觀	white powder
儲存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產品詳情

GSK2606414 is an orally available, selective protein kinase R-like ER kinase (PERK) inhibitor with an IC₅₀ value of 0.4 nM. It can inhibit thapsigargin-induced PERK phosphorylation in lung carcinoma A549 cells and attenuates subcutaneous pancreatic human tumor xenograft growth in mice. Because PERK mediates the unfolded protein response pathway, which has roles in neurotoxicity and cancer, inhibition of PERK signaling has potential applications for the treatment of cancer and also cognitive degeneration.

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CL1098

GSK2606414;GSK 2606414

1337531-36-8 98+% In-stock

￥520.00 20 mg