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首頁 > 產品目錄 > 信號通路 > Antibody-drug Conjugate/ADC Related > ADC Cytotoxin > 甲氨蝶呤

甲氨蝶呤

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Methotrexate

產品編號：CL2266 CAS No.：59-05-2 MDLNo： 分子式：C20H22N8O5 分子量：454.44
規格 庫存 目錄價 會員專享價 數量
250 mg In-stock ￥500.00 登錄后可見
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500 mg In-stock ￥800.00 登錄后可見
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1 g In-stock ￥1280.00 登錄后可見
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基本信息
英文名稱 Methotrexate
中文名稱甲氨蝶呤
CAS號59-05-2
分子式C20H22N8O5
分子量454.44
外觀Light yellow to yellow powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產品詳情

Methotrexate (MTX; alphamethopterin; amethopterin; methylaminopterin; CL-14377; NCIC04671; WR19039; NCI-C04671) is an FDA approved antineoplastic and immunosuppressant drug that belongs to the antimetabolite and antifolate class of drugs. It acts by inhibiting the metabolism of folic acid in activated peripheral T cells. Specifically, methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate (Amethopterin) is the disease-modifying antirheumatic drug (DMARD) of first choice for the treatment of RA in most countries worldwide. Methotrexate is an antineoplastic agent used to fight a number of different cancers, such as acute lymphoblastic leukemia and solid cancers.

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