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規格	庫存	目錄價	會員專享價	數量
5 mg	3-5days	￥636.00	登錄后可見	- +
10 mg	3-5days	￥1068.00	登錄后可見	- +

規格

庫存

目錄價

會員專享價

數量

5 mg

3-5days

￥636.00

登錄后可見

- +

10 mg

3-5days

￥1068.00

登錄后可見

- +

基本信息

英文名稱	Brivanib \| BMS-540215
中文名稱	布立尼布
CAS號	649735-46-6
分子式	C19H19FN4O3
分子量	370.38
外觀	White to light brown powder
儲存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產品詳情

Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with an IC₅₀ of 25 nM, and has moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β.

相關文獻

Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor.

PMID: 16570908 DOI: 10.1021/jm051106d

Correction: Brivanib Attenuates Hepatic Fibrosis In Vivo and Stellate Cell Activation In Vitro by Inhibition of FGF, VEGF and PDGF Signaling.

PMID: 26528545 PMCID: PMC4631495 DOI: 10.1371/journal.pone.0142355

Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma.

PMID: 18829493 DOI: 10.1158/1078-0432.CCR-08-0509

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