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首頁 > 產品目錄 > 信號通路 > TGF-beta/Smad | 信號通路 > PKC (蛋白激酶C) > Go 6983

Go 6983

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Go 6983

產品編號：CL2440 CAS No.：133053-19-7 MDLNo： 分子式：C26H26N4O3 分子量：442.51
規格 庫存 目錄價 會員專享價 數量
5 mg In-stock ￥600.00 登錄后可見
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10 mg In-stock ￥900.00 登錄后可見
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25 mg 3-5days ￥1575.00 登錄后可見
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基本信息
英文名稱 Go 6983
中文名稱Go 6983
CAS號133053-19-7
分子式C26H26N4O3
分子量442.51
外觀 Pink to red powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產品詳情

Go 6983 (also known as GOE-6983; Go-6983; GOE6983; Go6983) is a novel and potent pan-PKC (protein kinase C) inhibitor with potential anticancer and cardioprotective activity. It inhibits PKCα, PKCβ, PKCγ and PKCδ with IC50s of 7 nM, 7 nM, 6 nM and 10 nM, respectively. Go 6983 shows less potency against PKCζ and is inactive on PKCμ. GO6893 displays cardioprotective properties and can reduce polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. When tested with MCF-7 and T47D cells, Go 6983 showed reversible effect on the down-regulation of PKCαand PKCδ induced by PKC activator PDBu, while decreased the expression of PKCη which up-regulated by PDBu.

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