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首頁 > 產品目錄 > 信號通路 > Microbiology/Virology/ Anti-infection > Fungal > 4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-三唑-1-基)甲基)-5-(2,4-二氟苯基)四氫呋喃-3-基)甲氧基)苯基)哌嗪-1-基)苯基)-1-((2S,3S)-2-羥基戊-3-基)-1H-1,2,4-三唑-5(4H)-酮

4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-三唑-1-基)甲基)-5-(2,4-二氟苯基)四氫呋喃-3-基)甲氧基)苯基)哌嗪-1-基)苯基)-1-((2S,3S)-2-羥基戊-3-基)-1H-1,2,4-三唑-5(4H)-酮

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Posaconazole (Synonyms: SCH 56592; 泊沙康唑;)

產品編號：CL2521 CAS No.：171228-49-2 MDLNo：MFCD00941162 分子式：C37H42F2N8O4 分子量：700.78
規格 庫存 目錄價 會員專享價 數量
10 mg 3-5days ￥450.00 登錄后可見
- +
25 mg 3-5days ￥650.00 登錄后可見
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50 mg 3-5days ￥950.00 登錄后可見
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基本信息
英文名稱 Posaconazole (Synonyms: SCH 56592; 泊沙康唑;)
中文名稱4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-三唑-1-基)甲基)-5-(2,4-二氟苯基)四氫呋喃-3-基)甲氧基)苯基)哌嗪-1-基)苯基)-1-((2S,3S)-2-羥基戊-3-基)-1H-1,2,4-三唑-5(4H)-酮
CAS號171228-49-2
分子式C37H42F2N8O4
分子量700.78
MDLMFCD00941162
外觀White to off-white powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產品詳情

Posaconazole (also known as SCH 56592 or trade name of Noxafil) is a potent,broad-spectrum, second generation triazole antifungal compound that potently inhibits 14α-demethylation in a variety of fungi, including Candida and Aspergillus, with half maximal inhibition concentration IC50 of 0.007 μg/ml, 0.06 μg/ml, 0.2 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml respectively Posaconzole, an itraconzole derivative with fluorine replacing chlorine in the phenyl ring and hydroxylation in the side chain, binds to the heme cofactor on the active site of 14α-demethylase, which converts lanosterol to 14α-dimethy lanosterol, resulting in the disruption of the integrity and function of the fungal cell membrane and inhibition of fungal growth.

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