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Rebastinib (DCC-2036)

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Rebastinib (DCC-2036)

產(chǎn)品編號：CL2536 CAS No.：1020172-07-9 MDLNo： 分子式：C30H28FN7O3 分子量：553.59
規(guī)格 庫存 目錄價 會員專享價 數(shù)量
5 mg 3-5days ￥620.00 登錄后可見
- +
10 mg 3-5days ￥1000.00 登錄后可見
- +
25 mg 3-5days ￥1800.00 登錄后可見
- +

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基本信息
英文名稱 Rebastinib (DCC-2036)
中文名稱Rebastinib (DCC-2036)
CAS號1020172-07-9
分子式C30H28FN7O3
分子量553.59
外觀White to off-white powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Rebastinib (formerly also known as DCC-2036), a novel, potent and orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity, is a conformational control Bcr-Abl inhibitor for Abl1(WT) and Abl1(T315I) with IC50s of 0.8 nM and 4 nM. It also inhibits other kinases such as SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and has low activity towards c-Kit. DCC-2036 inhibits ABL1 through forcing the kinase domains into inhibitor-bound, inactive Type II conformations. In cellular assay, DCC-2036 inhibits the proliferation of Ba/F3 and K562 cells with IC50 values of 5.4nM and 5.5nM, respectively.

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