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噁拉戈利鈉

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Elagolix Sodium; NBI 56418NA; NBI-56418 sodium

產品編號:CL2564A CAS No.:832720-36-2 MDLNo: 分子式:C32H29F5N3NaO5 分子量:653.57
規格 庫存 目錄價 會員專享價 數量
5 mg 3-5days ¥400.00 登錄后可見
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10 mg 3-5days ¥650.00 登錄后可見
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基本信息
英文名稱 Elagolix Sodium; NBI 56418NA; NBI-56418 sodium
中文名稱噁拉戈利鈉
CAS號832720-36-2
分子式C32H29F5N3NaO5
分子量653.57
外觀White to light yellow powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產品詳情

Elagolix sodium (NBI56418; ABT-620; Orilissa), the sodium salt of Elagolix, is an orally bioavailable and small molecule antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (KD = 54 pM) approved on 7/23/2018 by FDA for the management of moderate to severe pain associated with endometriosis. Elagolix is a short-acting GnRH antagonist that suppresses ovarian estrogen production in a dose-dependent manner, meaning that higher doses result in full suppression while lower doses only cause partial suppression. Elagolix's non-peptide structure and oral bioavailability make it the leader of a new class of GnRH inhibitors known as second-generation inhibitors.

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