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首頁 > 產品目錄 > 信號通路 > Cell Cycle | 細胞周期 > DNA/RNA Synthesis > CX-5461

CX-5461

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CX-5461 | Pidnarulex

產品編號：CL2993 CAS No.：1138549-36-6 MDLNo： 分子式：C27H27N7O2S 分子量：513.61
規格 庫存 目錄價 會員專享價 數量
2 mg 3-5days ￥288.00 登錄后可見
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5 mg 3-5days ￥498.00 登錄后可見
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10 mg 3-5days ￥898.00 登錄后可見
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25 mg 3-5days ￥1616.00 登錄后可見
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基本信息
英文名稱 CX-5461 | Pidnarulex
中文名稱CX-5461
CAS號1138549-36-6
分子式C27H27N7O2S
分子量513.61
外觀White to yellow powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產品詳情

CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. CX-5461 selectively inhibits rRNA synthesis by Pol I in the nucleolus, but does not inhibit mRNA synthesis by RNA Polymerase II (Pol II) and does not inhibit DNA replication or protein synthesis. Inhibition of Pol I results in nucleolar stress and release of ribosomal proteins (RP) from the nucleolus. The RP bind to Mdm2 and liberate p53 to orchestrate apoptosis in cancer cells. CX-5461 demonstrates a favorable preclinical profile, potently and selectively kills cancer cells, demonstrates robust in vivo efficacy in multiple models, and has demonstrated oral bioavailability in multiple species.


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