英文名稱 | Sibeprenlimab (Synonyms: VIS649) |
---|---|
中文名稱 | 西貝瑞單抗 |
CAS號 | 2382896-07-1 |
儲存條件 | store at -80°C | Shipping with blue ice. |
英文名稱 | Sibeprenlimab (Synonyms: VIS649) |
---|---|
中文名稱 | 西貝瑞單抗 |
CAS號 | 2382896-07-1 |
儲存條件 | store at -80°C | Shipping with blue ice. |
Sibeprenlimab (VIS649), a humanized IgG2 monoclonal antibody, neutralizes APRIL, a key factor in IgA nephropathy (IgAN) pathogenesis. It effectively reduces pathogenic IgA and IgM while preserving vaccine responses to SARS-CoV-2 mRNA-based vaccines. Clinical trials demonstrate that sibeprenlimab decreases UPCR and stabilizes GFR, positioning it as a promising treatment for IgAN.
Arginine or Hypertonic Saline-Stimulated Copeptin to Diagnose AVP Deficiency.
PMID: 37966286 DOI: 10.1056/NEJMoa2306263
PMID: 37959392 PMCID: PMC10650434 DOI: 10.3390/jcm12216927
PMID: 35570983 PMCID: PMC9091613 DOI: 10.1016/j.ekir.2022.01.1073