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首頁 > 產品目錄 > 信號通路 > Stem Cells & Wnt | 干細胞及 Wnt 通路 > ROCK > trans-4-[(R)-1-氨基乙基]-N-(4-吡啶基)環己烷甲酰胺二鹽酸鹽 | Y-27632 二鹽酸鹽 | (R)-(+)-反式-4-(1-氨基乙基)-N-(4-吡啶基)環己烷甲酰胺二鹽酸鹽

trans-4-[(R)-1-氨基乙基]-N-(4-吡啶基)環己烷甲酰胺二鹽酸鹽 | Y-27632 二鹽酸鹽 | (R)-(+)-反式-4-(1-氨基乙基)-N-(4-吡啶基)環己烷甲酰胺二鹽酸鹽

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Y-27632 Dihydrochloride (Synonyms: Y-27632 2HCl ; trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride)

產品編號：CL1003 CAS No.：129830-38-2 MDLNo：MFCD03490488 分子式：C14H21N3O.2HCl 分子量：320.26 | 247.34(free)

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規格	庫存	目錄價	會員專享價	數量
5 mg	In-stock	￥650.00	登錄后可見	- +
10 mg	In-stock	￥900.00	登錄后可見	- +
25 mg	In-stock	￥1600.00	登錄后可見	- +
50 mg	In-stock	￥2636.00	登錄后可見	- +

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基本信息

英文名稱	Y-27632 Dihydrochloride (Synonyms: Y-27632 2HCl ; trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride)
中文名稱	trans-4-[(R)-1-氨基乙基]-N-(4-吡啶基)環己烷甲酰胺二鹽酸鹽 \| Y-27632 二鹽酸鹽 \| (R)-(+)-反式-4-(1-氨基乙基)-N-(4-吡啶基)環己烷甲酰胺二鹽酸鹽
CAS號	129830-38-2
分子式	C14H21N3O.2HCl
分子量	320.26 \| 247.34(free)
MDL	MFCD03490488
外觀	White to off-white powder
儲存條件	4°C, sealed storage, away from moisture

產品詳情

The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 2HClis a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM). It also inhibits PRK2 with an IC50 value of 600 nM. One-hour treatment with 10 μMY-27632 2HCl blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages.