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2-嗎啉-8-苯基-4H-苯并吡喃-4-酮

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LY294002 (Synonyms: NSC 697286 ; SF 1101 )

產(chǎn)品編號:CL1320 CAS No.:154447-36-6 MDLNo:MFCD00270881 分子式:C19H17NO3 分子量:307.34
規(guī)格 庫存 目錄價(jià) 會員專享價(jià) 數(shù)量
5 mg 3-5days ¥326.00 登錄后可見
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10 mg 3-5days ¥566.00 登錄后可見
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50 mg 3-5days ¥1288.00 登錄后可見
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  • 基本信息
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基本信息
英文名稱 LY294002 (Synonyms: NSC 697286 ; SF 1101 )
中文名稱2-嗎啉-8-苯基-4H-苯并吡喃-4-酮
CAS號154447-36-6
分子式C19H17NO3
分子量307.34
MDLMFCD00270881
外觀White to yellow powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

LY294002, a morpholine-containing compound designed based on the flavonoid quercetin, is a potent and cell-permeable PI3K inhibitor, inhibiting PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM in cell-free assays, respectively. Additionally, it inhibits BET (for example, BRD2, BRD3, and BRD4). It is more stable in solutions than the PI3K inhibitor Wortmannin. By acting on the ATP binding site of the catalytic subunit of PI3K, LY294002 is selective against p110α, p110β, p110γ and p110δ.

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